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Benzoxazole derivatives as new VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, in silico studies, and antiproliferative evaluation.

ABSTRACT: In this study, a set of novel benzoxazole derivatives were designed, synthesised, and biologically evaluated as potential VEGFR-2 inhibitors. Five compounds (12d, 12f, 12i, 12l, and 13a) displayed high growth inhibitory activities against HepG2 and MCF-7 cell lines and were further investigated for their VEGFR-2 inhibitory activities. The most potent anti-proliferative member 12 l (IC₅₀ = 10.50 μM and 15.21 μM against HepG2 and MCF-7, respectively) had the most promising VEGFR-2 inhibitory activity (IC₅₀ = 97.38 nM). A further biological evaluation revealed that compound 12l could arrest the HepG2 cell growth mainly at the Pre-G1 and G1 phases. Furthermore, compound 12l could induce apoptosis in HepG2 cells by 35.13%. likely, compound 12l exhibited a significant elevation in caspase-3 level (2.98-fold) and BAX (3.40-fold), and a significant reduction in Bcl-2 level (2.12-fold). Finally, docking studies indicated that 12l exhibited interactions with the key amino acids in a similar way to sorafenib.

SUBMITTER: Taghour MS

PROVIDER: S-EPMC9327782 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Benzoxazole derivatives as new VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, in silico studies, and antiproliferative evaluation.

Taghour Mohammed S MS Mahdy Hazem A HA Gomaa Maher H MH Aglan Ahmed A Eldeib Mahmoud Gomaa MG Elwan Alaa A Dahab Mohammed A MA Elkaeed Eslam B EB Alsfouk Aisha A AA Khalifa Mohamed M MM Eissa Ibrahim H IH Elkady Hazem H

Journal of enzyme inhibition and medicinal chemistry 20221201 1

In this study, a set of novel benzoxazole derivatives were designed, synthesised, and biologically evaluated as potential VEGFR-2 inhibitors. Five compounds (12d, 12f, 12i, 12l, and 13a) displayed high growth inhibitory activities against HepG2 and MCF-7 cell lines and were further investigated for their VEGFR-2 inhibitory activities. The most potent anti-proliferative member 12 l (IC50 = 10.50 μM and 15.21 μM against HepG2 and MCF-7, respecti ...[more]

PMID: 35875937

Dataset Information

Benzoxazole derivatives as new VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, in silico studies, and antiproliferative evaluation.

Publications

Benzoxazole derivatives as new VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, <i>in silico</i> studies, and antiproliferative evaluation.

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