Ontology highlight
ABSTRACT:
SUBMITTER: Razumikhin M
PROVIDER: S-EPMC9328115 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Razumikhin Mikhail M Smolyanova Tatiana T Nikolaeva Alevtina A Orlova Ekaterina E Ivanov Aleksandr A Belyakova Olga O Vyaznikova Tatyana T Selezneva Natalia N Perevozchikov Anton A Sokolova Alina A Zubkova Nataliya N Efimova Irina I Dolzhikova Inna I Logunov Denis D Sakanjan Elena E
Immunotherapy 20220727 14
<b>Background:</b> The authors describe the developmental process of intravenous anti-COVID-19 hyperimmune immunoglobulin from anti-SARS-CoV-2 neutralizing antibody-containing plasma. Furthermore, the authors investigated its safety and protective activity in animal models. <b>Materials & methods:</b> The manufacturing process included standard ethanol fractionation, chromatographic purification steps and virus removal or inactivation. <b>Results:</b> The authors produced pure and safe immunoglo ...[more]