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Circ_0000144 acts as a miR-1178-3p decoy to promote cell malignancy and angiogenesis by increasing YWHAH expression in papillary thyroid cancer

ABSTRACT: Papillary thyroid cancer (PTC) is the most common subtype of thyroid cancer. Circular RNA hsa_circ_0000144 (circ_0000144) is related to the progression of thyroid cancer. However, the mechanism by which circ_0000144 accelerates PTC progression is still unclear. Circ_0000144 and YWHAH were upregulated in PTC tissues and cells, while miR-1178-3p had an opposite result. Circ_0000144 silencing constrained PTC cell growth in vitro and in vivo and induced apoptosis and repressed migration, invasion, and angiogenesis of PTC cells in vitro. Circ_0000144 acted as a molecular sponge for miR-1178-3p, which targeted YWHAH. MiR-1178-3p inhibitor reversed circ_0000144 silencing-mediated influence on PTC cell malignancy and angiogenesis. Furthermore, YWHAH overexpression overturned miR-1178-3p mimic-mediated influence on malignant behaviors and angiogenesis of PTC cells. Notably, circ_0000144 regulated YWHAH expression by adsorbing miR-1178-3p. Circ_0000144 promoted cell malignancy and angiogenesis by regulating the miR-1178-3p/YWHAH axis in PTC, offering a novel mechanism for the malignancy and angiogenesis of PTC cells.

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Supplementary Information

The online version contains supplementary material available at 10.1186/s40463-022-00574-w. Highlights Inhibition of circ_0000144 repressed malignant behaviors and angiogenesis of PTC cells in vitro. Knockdown of circ_0000144 constrained PTC cell proliferation in vivo. Circ_0000144 acted as a miR-1178-3p sponge. YWHAH acted as a downstream target for miR-1178-3p.

Supplementary Information

The online version contains supplementary material available at 10.1186/s40463-022-00574-w.

SUBMITTER: Ma Y

PROVIDER: S-EPMC9330660 | biostudies-literature |

REPOSITORIES: biostudies-literature

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