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One-Pot Route from Halogenated Amides to Piperidines and Pyrrolidines.

ABSTRACT: Piperidine and pyrrolidine derivatives are important nitrogen heterocyclic structures with a wide range of biological activities. However, reported methods for their construction often face problems of requiring the use of expensive metal catalysts, highly toxic reaction reagents or hazardous reaction conditions. Herein, an efficient route from halogenated amides to piperidines and pyrrolidines was disclosed. In this method, amide activation, reduction of nitrile ions, and intramolecular nucleophilic substitution were integrated in a one-pot reaction. The reaction conditions were mild and no metal catalysts were used. The synthesis of a variety of N-substituted and some C-substituted piperidines and pyrrolidines became convenient, and good yields were obtained.

SUBMITTER: Song Q

PROVIDER: S-EPMC9331508 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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One-Pot Route from Halogenated Amides to Piperidines and Pyrrolidines.

Song Qiao Q Wang Sheng S Lei Xiangui X Liu Yan Y Wen Xin X Wang Zhouyu Z

Molecules (Basel, Switzerland) 20220722 15

Piperidine and pyrrolidine derivatives are important nitrogen heterocyclic structures with a wide range of biological activities. However, reported methods for their construction often face problems of requiring the use of expensive metal catalysts, highly toxic reaction reagents or hazardous reaction conditions. Herein, an efficient route from halogenated amides to piperidines and pyrrolidines was disclosed. In this method, amide activation, reduction of nitrile ions, and intramolecular nucleop ...[more]

PMID: 35897866

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