Dataset Information

Causal Associations between Paternal Longevity and Risks of Cardiovascular Diseases.

ABSTRACT:

Background

Observational studies have suggested that paternal longevity is associated with reduced risks of cardiovascular diseases, yet the causal association remains to be determined.

Objectives

To investigate whether Mendelian randomization (MR) results support a causal role of paternal longevity for risks of cardiovascular diseases.

Methods

Genetic variants associated with paternal longevity and cardiovascular diseases were obtained from public genome-wide association study data. We used inverse variance weighted MR under a random-effects model to provide causal estimates between paternal longevity and cardiovascular diseases.