Proteins induced during adaptation of Acetobacter aceti to high acetate concentrations.

ABSTRACT: As a typical product of microbial metabolism, the weak acid acetate is well known for its cytotoxic effects. In contrast to most other microbes, the so-called acetic acid bacteria can acquire significant resistance to high acetate concentrations when properly adapted to such hostile conditions. To characterize the molecular events that are associated with this adaptation, we analyzed global protein expression levels during adaptation of Acetobacter aceti by two-dimensional gel electrophoresis. Adaptation was achieved by using serial batch and continuous cultivations with increasing acetate supplementation. Computer-aided analysis revealed a complex proteome response with at least 50 proteins that are specifically induced by adaptation to acetate but not by other stress conditions, such as

SUBMITTER: Steiner P 

PROVIDER: S-EPMC93332 | biostudies-literature | 2001 Dec

REPOSITORIES: biostudies-literature