Role of ferroptosis-related genes in periodontitis based on integrated bioinformatics analysis.

ABSTRACT:

Background

Cell survival or death is one of the key scientific issues of inflammatory response. To regulate cell death during the occurrence and development of periodontitis, various forms of programmed cell death, such as pyroptosis, ferroptosis, necroptosis, and apoptosis, have been proposed. It has been found that ferroptosis characterized by iron-dependent lipid peroxidation is involved in cancer, degenerative brain diseases and inflammatory diseases. Furthermore, NCOA4 is considered one of ferroptosis-related genes (FRGs) contributing to butyrate-induced cell death in the periodontitis. This research aims to analyze the expression of FRGs in periodontitis tissues and to explore the relationship between ferroptosis and periodontitis.

Method

Genes associated with periodon

SUBMITTER: Zhang S 

PROVIDER: S-EPMC9333299 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature