Unknown

Dataset Information

0

Design, Synthesis, and Bioactivities of Novel Trifluoromethyl Pyrimidine Derivatives Bearing an Amide Moiety.

ABSTRACT: Twenty-three novel trifluoromethyl pyrimidine derivatives containing an amide moiety were designed and synthesized through four-step reactions and evaluated for their antifungal, insecticidal, and anticancer properties. Bioassay results indicated that some of the title compounds exhibited good in vitro antifungal activities against Botryosphaeria dothidea (B. dothidea), Phompsis sp., Botrytis cinereal (B. cinerea), Colletotrichum gloeosporioides (C. gloeosporioides), Pyricutaria oryzae (P. oryzae), and Sclerotinia sclerotiorum (S. sclerotiorum) at 50 μg/ml. Meanwhile, the synthesized compounds showed moderate insecticidal activities against Mythimna separata (M. separata) and Spdoptera frugiperda (S. frugiperda) at 500 μg/ml, which were lower than those of chlorantraniliprole. In addition, the synthesized compounds indicated certain anticancer activities against PC3, K562, Hela, and A549 at 5 μg/ml, which were lower than those of doxorubicin. Notably, this work is the first report on the antifungal, insecticidal, and anticancer activities of trifluoromethyl pyrimidine derivatives bearing an amide moiety.

SUBMITTER: Lan W 

PROVIDER: S-EPMC9334529 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Design, Synthesis, and Bioactivities of Novel Trifluoromethyl Pyrimidine Derivatives Bearing an Amide Moiety.

Lan Wenjun W   Tang Xuemei X   Yu Jia J   Fei Qiang Q   Wu Wenneng W   Li Pei P   Luo Heng H  

Frontiers in chemistry 20220715

Twenty-three novel trifluoromethyl pyrimidine derivatives containing an amide moiety were designed and synthesized through four-step reactions and evaluated for their antifungal, insecticidal, and anticancer properties. Bioassay results indicated that some of the title compounds exhibited good <i>in vitro</i> antifungal activities against <i>Botryosphaeria dothidea</i> (<i>B. dothidea</i>), <i>Phompsis</i> sp., <i>Botrytis cinereal</i> (<i>B. cinerea</i>), <i>Colletotrichum gloeosporioides</i> (  ...[more]

Similar Datasets

Unknown Synthesis and Bioactivities Study of Novel Pyridylpyrazol Amide Derivatives Containing Pyrimidine Motifs.
| S-EPMC7411148 | biostudies-literature
Unknown Synthesis and Antifungal Activity of Pyrimidine Derivatives Containing an Amide Moiety.
| S-EPMC8311460 | biostudies-literature
Unknown Rational Design and Synthesis of Diverse Pyrimidine Molecules Bearing Sulfonamide Moiety as Novel ERK Inhibitors.
| S-EPMC6888105 | biostudies-literature
Unknown Novel Pyrimidine Derivatives Bearing a 1,3,4-Thiadiazole Skeleton: Design, Synthesis, and Antifungal Activity
| S-EPMC9213879 | biostudies-literature
Unknown Design, Synthesis and Bioactivities of Novel 1,4-Pentadien-3-one Derivatives Containing a Substituted Pyrazolyl Moiety.
| S-EPMC6152210 | biostudies-literature
Unknown Design, Synthesis, and Biological Evaluation of Novel Benzofuran Derivatives Bearing N-Aryl Piperazine Moiety.
| S-EPMC6274084 | biostudies-literature
Unknown Synthesis and Bioactivities of Novel Galactoside Derivatives Containing 1,3,4-Thiadiazole Moiety.
| S-EPMC9160659 | biostudies-literature
Unknown Design, synthesis and SAR study of novel trisubstituted pyrimidine amide derivatives as CCR4 antagonists.
| S-EPMC6271259 | biostudies-literature
Unknown Design, synthesis, insecticidal activity and 3D-QSR study for novel trifluoromethyl pyridine derivatives containing an 1,3,4-oxadiazole moiety.
| S-EPMC9078298 | biostudies-literature
Unknown Sulfonate derivatives bearing an amide unit: design, synthesis and biological activity studies.
| S-EPMC10919044 | biostudies-literature