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COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022.

ABSTRACT: This work evaluated neutralising antibody titres against wild type (WT) SARS-CoV-2 and four Omicron variants (BA.1, BA.2, BA.4 and BA.5) in healthcare workers who had breakthrough BA.1 infection. Omicron breakthrough infection in individuals vaccinated three or four times before infection resulted in increased neutralising antibodies against the WT virus. The fourth vaccine dose did not further improve the neutralising efficiency over the third dose against all Omicron variants, especially BA.4 and BA.5. An Omicron-specific vaccine may be indicated.

SUBMITTER: Kliker L

PROVIDER: S-EPMC9336169 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022.

Kliker Limor L Zuckerman Neta N Atari Nofar N Barda Noam N Gilboa Mayan M Nemet Ital I Abd Elkader Bayan B Fratty Ilana S IS Jaber Hanaa H Mendelson Ella E Alroy-Preis Sharon S Kreiss Yitshak Y Regev-Yochay Gili G Mandelboim Michal M

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20220701 30

This work evaluated neutralising antibody titres against wild type (WT) SARS-CoV-2 and four Omicron variants (BA.1, BA.2, BA.4 and BA.5) in healthcare workers who had breakthrough BA.1 infection. Omicron breakthrough infection in individuals vaccinated three or four times before infection resulted in increased neutralising antibodies against the WT virus. The fourth vaccine dose did not further improve the neutralising efficiency over the third dose against all Omicron variants, especially BA.4 ...[more]

PMID: 35904058

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