Ontology highlight
ABSTRACT:
SUBMITTER: Jiang S
PROVIDER: S-EPMC9337765 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Jiang Shan S Wang Yi-Song YS Zheng Xiao-Xia XX Zhao Shan-Lan SL Wang Yi Y Sun Lin L Chen Peng-Hui PH Zhou Yi Y Tin Chung C Li Hong-Li HL Sui Jian-Feng JF Wu Guang-Yan GY
Science advances 20220729 30
Itch is a cutaneous sensation that is critical in driving scratching behavior. The long-standing question of whether there are specific neurons for itch modulation inside the brain remains unanswered. Here, we report a subpopulation of itch-specific neurons in the ventrolateral orbital cortex (VLO) that is distinct from the pain-related neurons. Using a Tet-Off cellular labeling system, we showed that local inhibition or activation of these itch-specific neurons in the VLO significantly suppress ...[more]