Unknown

Dataset Information

0

Itch-specific neurons in the ventrolateral orbital cortex selectively modulate the itch processing.


ABSTRACT: Itch is a cutaneous sensation that is critical in driving scratching behavior. The long-standing question of whether there are specific neurons for itch modulation inside the brain remains unanswered. Here, we report a subpopulation of itch-specific neurons in the ventrolateral orbital cortex (VLO) that is distinct from the pain-related neurons. Using a Tet-Off cellular labeling system, we showed that local inhibition or activation of these itch-specific neurons in the VLO significantly suppressed or enhanced itch-induced scratching, respectively, whereas the intervention did not significantly affect pain. Conversely, suppression or activation of pain-specific neurons in the VLO significantly affected pain but not itch. Moreover, fiber photometry and immunofluorescence verified that these itch- and pain-specific neurons are distinct in their functional activity and histological location. In addition, the downstream targets of itch- and pain-specific neurons were different. Together, the present study uncovers an important subpopulation of neurons in the VLO that specifically modulates itch processing.

SUBMITTER: Jiang S 

PROVIDER: S-EPMC9337765 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Itch-specific neurons in the ventrolateral orbital cortex selectively modulate the itch processing.

Jiang Shan S   Wang Yi-Song YS   Zheng Xiao-Xia XX   Zhao Shan-Lan SL   Wang Yi Y   Sun Lin L   Chen Peng-Hui PH   Zhou Yi Y   Tin Chung C   Li Hong-Li HL   Sui Jian-Feng JF   Wu Guang-Yan GY  

Science advances 20220729 30


Itch is a cutaneous sensation that is critical in driving scratching behavior. The long-standing question of whether there are specific neurons for itch modulation inside the brain remains unanswered. Here, we report a subpopulation of itch-specific neurons in the ventrolateral orbital cortex (VLO) that is distinct from the pain-related neurons. Using a Tet-Off cellular labeling system, we showed that local inhibition or activation of these itch-specific neurons in the VLO significantly suppress  ...[more]

Similar Datasets

| S-EPMC11880300 | biostudies-literature
| S-EPMC7566721 | biostudies-literature
| S-EPMC11578322 | biostudies-literature
| S-EPMC5349536 | biostudies-literature
| S-EPMC3536774 | biostudies-literature
| S-EPMC10717118 | biostudies-literature
| S-EPMC9816985 | biostudies-literature
| S-EPMC5600902 | biostudies-literature
| S-EPMC5496820 | biostudies-literature
| S-EPMC5465388 | biostudies-literature