Dataset Information

Neurological manifestations by sex and age group in COVID-19 inhospital patients.

ABSTRACT:

Introduction

Neurological manifestations have been associated with a poorer prognosis in COVID-19. However, data regarding their incidence according to sex and age groups is still lacking.

Methods

This retrospective multicentric cohort collected data from 39 Brazilian hospitals from 17 cities, from adult COVID-19 admitted from March 2020 to January 2022. Neurological manifestations presented at hospital admission were assessed according to incidence by sex and age group.

Results

From 13,603 COVID-19 patients, median age was 60 years old and 53.0% were men. Women were more likely to present with headaches (22.4% vs. 17.7%, p < 0.001; OR 1.36, 95% confidence interval [CI] 1.22-1.52) than men and also presented a lower risk of having seizures (OR 0.43, 95% CI 0.20-0.94). Although delirium was more frequent in women (6.6% vs. 5.7%, p = 0.020), sex was not associated with delirium in the multivariable logistc regresssion analysis. Delirium, syncope and coma increased with age (1.5% [18-39 years] vs. 22.4% [80 years or over], p < 0.001, OR 1.07, 95% CI 1.06-1.07; 0.7% vs. 1.7%, p = 0.002, OR 1.01, 95% CI 1.00-1.02; 0.2% vs. 1.3% p < 0.001, OR 1.04, 95% CI 1.02-1.06), while, headache (26.5% vs. 7.1%, OR 0.98, 95% CI 0.98-0.99), anosmia (11.4% vs. 3.3%, OR 0.99, 95% CI] 0.98-0.99 and ageusia (13.1% vs. 3.5%, OR 0.99, CI 0.98-0.99) decreased (p < 0.001 for all).

Conclusion

Older COVID-19 patients were more likely to present delirium, syncope and coma, while the incidence of anosmia, ageusia and headaches decreased with age. Women were more likely to present headache, and less likely to present seizures.

SUBMITTER: Pereira DN

PROVIDER: S-EPMC9338167 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Publications

Neurological manifestations by sex and age group in COVID-19 inhospital patients.

Pereira Daniella Nunes DN Bicalho Maria Aparecida Camargos MAC Jorge Alzira de Oliveira AO Gomes Angélica Gomides Dos Reis AGDR Schwarzbold Alexandre Vargas AV Araújo Anna Luiza Homan ALH Cimini Christiane Corrêa Rodrigues CCR Ponce Daniela D Rios Danyelle Romana Alves DRA Grizende Genna Maira Santos GMS Manenti Euler Roberto Fernandes ERF Anschau Fernando F Aranha Fernando Graça FG Bartolazzi Frederico F Batista Joanna d'Arc Lyra JDL Tupinambás Julia Teixeira JT Ruschel Karen Brasil KB Ferreira Maria Angélica Pires MAP Paraíso Pedro Gibson PG Araújo Silvia Ferreira SF Teixeira Antonio Lucio AL Marcolino Milena Soriano MS

eNeurologicalSci 20220730

<h4>Introduction</h4>Neurological manifestations have been associated with a poorer prognosis in COVID-19. However, data regarding their incidence according to sex and age groups is still lacking.<h4>Methods</h4>This retrospective multicentric cohort collected data from 39 Brazilian hospitals from 17 cities, from adult COVID-19 admitted from March 2020 to January 2022. Neurological manifestations presented at hospital admission were assessed according to incidence by sex and age group.<h4>Result ...[more]

PMID: 35935176

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Project description:Background and objectiveCOVID-19 neurological manifestations have been progressively recognized. Among available MRI techniques, diffusion weighted imaging (DWI) shows promise to study microstructure, inflammation, and edema. Previous DWI studies reported alterations in brain diffusivity in COVID-19 patients, as assessed by morphologic evaluation of brain DWI scans only. The aim of this study was to assess and quantify brain diffusion alterations in COVID-19 patients with neurological manifestations.Methods215 COVID-19 patients with neurological manifestations (olfactory and/or other neurological disorders) and 36 normal controls were compared and studied with DWI and T1-weighted MRI scans. MRI scans were processed by a semi-automatic processing procedure specifically developed for the purpose of this study, and the Apparent Diffusion Coefficient (ADC) was quantified in different brain tissues and individual white matter (WM) and gray matter (GM) regions. Differences in ADC values were assessed between COVID-19 patients and normal controls, as well as in the COVID-19 patient population grouped by hospitalization and neurological symptoms.ResultsAmong COVID-19 patients (median [IQR] = 52 [42 - 60] years of age, 58 % females), 91 were hospitalized and 26 needed intensive care. 84 patients had hyposmia/ageusia only, while 131 ones showed other neurological disorders. COVID-19 patients showed significantly increased ADC values in the WM and in several GM regions (p < 0.001). ADC values were significantly correlated with MRI time from disease onset (p < 0.05). Hospitalized patients showed significantly higher ADC alteration than non-hospitalized patients in all brain tissues; similarly, COVID-19 patients with neurological disorders showed significantly higher ADC values than those with olfactory loss only. ADC alteration was highest in patients with cognitive or memory disorder and in those with encephalitis or meningitis. ADC values were neither associated with the duration of hospitalization nor with the need for intensive care.ConclusionCurrent findings suggest DWI potential as a non-invasive marker of neuroinflammation in COVID-19, and the transient nature of the same. Future longitudinal studies are needed to confirm our findings.

Dataset Information

Neurological manifestations by sex and age group in COVID-19 inhospital patients.

Introduction

Methods

Results

Conclusion

Publications

Neurological manifestations by sex and age group in COVID-19 inhospital patients.

Similar Datasets

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