Ontology highlight
ABSTRACT:
SUBMITTER: del Rio A
PROVIDER: S-EPMC9339221 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
del Rio Armando A Perez-Jimenez Raul R Liu Ruchuan R Roca-Cusachs Pere P Fernandez Julio M JM Sheetz Michael P MP
Science (New York, N.Y.) 20090101 5914
The molecular mechanism by which a mechanical stimulus is translated into a chemical response in biological systems is still unclear. We show that mechanical stretching of single cytoplasmic proteins can activate binding of other molecules. We used magnetic tweezers, total internal reflection fluorescence, and atomic force microscopy to investigate the effect of force on the interaction between talin, a protein that links liganded membrane integrins to the cytoskeleton, and vinculin, a focal adh ...[more]