Ontology highlight
ABSTRACT: Background
Anastomotic complications are common after lung transplantation (1.4-33% of cases) and still associated with a high morbi-mortality.Methods
The current study is a monocenter retrospective analysis of symptomatic anastomotic complications (SAC) occurring after lung transplantation between 2010 and 2016, using the macroscopic, diameter, and suture (M-D-S) classification from consensus of French experts in bronchoscopy. The objectives were to determine incidence from surgery, risk factors, and impact of survival of SAC. We defined SAC as M-D-S abnormalities (stenosis ⩾ 50% or dehiscence) requiring bronchoscopic or surgical interventions.Results
A total of 121 patients were included. SAC occurred in 26.5% of patients (n = 32), divided in symptomatic stenosis for 23.7% (n = 29), and symptomatic dehiscence in 2.5% (n = 3). In multivariate analysis, donor bacterial lung infection [HR 2.08 (1.04-4.17), p = 0.04] and age above 50 years [HR 3.26 (1.04-10.26), p = 0.04] were associated with SAC occurrence. Cystic fibrosis etiology was associated with better survival on Kaplan-Meier curve (p < 0.001). SAC [HR 2.15 (1.07-4.32), p = 0.03] was independently associated with worst survival. The 29 symptomatic patients because of stenosis required endoscopic procedure, of whom 16 patients needed bronchial stent placement. Four patients underwent surgery: three patients because of dehiscence and one because of severe bilateral stenosis (re-transplantation).Discussion
SAC occurred in 26.5% of patients. Donor lung infection was the only alterable identified factors. The increase rate of SAC in older patients above 50 years of age encourages in regular endoscopic monitoring.
SUBMITTER: Delbove A
PROVIDER: S-EPMC9340386 | biostudies-literature | 2022 Jan-Dec
REPOSITORIES: biostudies-literature
Delbove Agathe A Senage Thomas T Gazengel Pierre P Tissot Adrien A Lacoste Philippe P Cellerin Laurent L Perigaud Christian C Danner-Boucher Isabelle I Cavailles Arnaud A Lepoivre Thierry T Mugniot Antoine A Nicolet Johanna J Horeau-Langlard Delphine D Groleau Nicolas N Fedun Yannick Y Rozec Bertrand B Magnan Antoine A Roussel Jean-Christian JC Blanc François-Xavier FX
Therapeutic advances in respiratory disease 20220101
<h4>Background</h4>Anastomotic complications are common after lung transplantation (1.4-33% of cases) and still associated with a high morbi-mortality.<h4>Methods</h4>The current study is a monocenter retrospective analysis of symptomatic anastomotic complications (SAC) occurring after lung transplantation between 2010 and 2016, using the macroscopic, diameter, and suture (M-D-S) classification from consensus of French experts in bronchoscopy. The objectives were to determine incidence from surg ...[more]