Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC9344965 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Liu Yingzi Y Guerrero-Juarez Christian F CF Xiao Fei F Shettigar Nitish Udupi NU Ramos Raul R Kuan Chen-Hsiang CH Lin Yuh-Charn YC de Jesus Martinez Lomeli Luis L Park Jung Min JM Oh Ji Won JW Liu Ruiqi R Lin Sung-Jan SJ Tartaglia Marco M Yang Ruey-Bing RB Yu Zhengquan Z Nie Qing Q Li Ji J Plikus Maksim V MV
Developmental cell 20220630 14
Hair follicle stem cells are regulated by dermal papilla fibroblasts, their principal signaling niche. Overactivation of Hedgehog signaling in the niche dramatically accelerates hair growth and induces follicle multiplication in mice. On single-cell RNA sequencing, dermal papilla fibroblasts increase heterogeneity to include new Wnt5a<sup>high</sup> states. Transcriptionally, mutant fibroblasts activate regulatory networks for Gli1, Alx3, Ebf1, Hoxc8, Sox18, and Zfp239. These networks jointly up ...[more]