Dataset Information

Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer.

ABSTRACT:

Background

Although high T cell density is a strong favourable prognostic factor in colorectal cancer, the significance of the spatial distribution of T cells is incompletely understood. We aimed to evaluate the prognostic significance of tumour cell-T cell co-localisation and T cell densities.

Methods

We analysed CD3 and CD8 immunohistochemistry in a study cohort of 983 colorectal cancer patients and a validation cohort (N = 246). Individual immune and tumour cells were identified to calculate T cell densities (to derive T cell density score) and G-cross function values, estimating the likelihood of tumour cells being co-located with T cells within 20 µm radius (to derive T cell proximity score).

Results

High T cell proximity score associated with longer cancer-specific survival in both the study cohort [adjusted HR for high (vs. low) 0.33, 95% CI 0.20-0.52, P_trend < 0.0001] and the validation cohort [adjusted HR for high (vs. low) 0.15, 95% CI 0.05-0.45, P_trend < 0.0001] and its prognostic value was independent of T cell density score.

Conclusions

The spatial point pattern analysis of tumour cell-T cell co-localisation could provide detailed information on colorectal cancer prognosis, supporting the value of spatial measurement of T cell infiltrates as a novel, robust tumour-immune biomarker.

SUBMITTER: Elomaa H

PROVIDER: S-EPMC9345858 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Publications

Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer.

Elomaa Hanna H Ahtiainen Maarit M Väyrynen Sara A SA Ogino Shuji S Nowak Jonathan A JA Friman Marjukka M Helminen Olli O Wirta Erkki-Ville EV Seppälä Toni T TT Böhm Jan J Mäkinen Markus J MJ Mecklin Jukka-Pekka JP Kuopio Teijo T Väyrynen Juha P JP

British journal of cancer 20220421 3

<h4>Background</h4>Although high T cell density is a strong favourable prognostic factor in colorectal cancer, the significance of the spatial distribution of T cells is incompletely understood. We aimed to evaluate the prognostic significance of tumour cell-T cell co-localisation and T cell densities.<h4>Methods</h4>We analysed CD3 and CD8 immunohistochemistry in a study cohort of 983 colorectal cancer patients and a validation cohort (N = 246). Individual immune and tumour cells were identifie ...[more]

PMID: 35449453

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Dataset Information

Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer.

Background

Methods

Results

Conclusions

Publications

Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer.

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