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Intracranial recordings show evidence of numerosity tuning in human parietal cortex.

ABSTRACT: Numerosity is the set size of a group of items. Numerosity perception is a trait shared across numerous species. Numerosity-selective neural populations are thought to underlie numerosity perception. These neurons have been identified primarily using electrical recordings in animal models and blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) in humans. Here we use electrical intracranial recordings to investigate numerosity tuning in humans, focusing on high-frequency transient activations. These recordings combine a high spatial and temporal resolution and can bridge the gap between animal models and human recordings. In line with previous studies, we find numerosity-tuned responses at parietal sites in two out of three participants. Neuronal populations at these locations did not respond to other visual stimuli, i.e. faces, houses, and letters, in contrast to several occipital sites. Our findings further corroborate the specificity of numerosity tuning of in parietal cortex, and further link fMRI results and electrophysiological recordings.

SUBMITTER: van Dijk JA

PROVIDER: S-EPMC9348694 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Intracranial recordings show evidence of numerosity tuning in human parietal cortex.

van Dijk Jelle A JA de Jong Maartje C MC Piantoni Gio G Fracasso Alessio A Vansteensel Mariska J MJ Groen Iris I A IIA Petridou Natalia N Dumoulin Serge O SO

PloS one 20220803 8

Numerosity is the set size of a group of items. Numerosity perception is a trait shared across numerous species. Numerosity-selective neural populations are thought to underlie numerosity perception. These neurons have been identified primarily using electrical recordings in animal models and blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) in humans. Here we use electrical intracranial recordings to investigate numerosity tuning in humans, focusing on high-freque ...[more]

PMID: 35921261

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Project description:ObjectiveNon-literal expressions such as sarcasm, metaphor and simile refer to words and sentences that convey meanings or intentions that are different and more abstract than literal expressions. Neuroimaging studies have shown activations in a variety of frontal, parietal and temporal brain regions implicated in non-literal language processing. However, neurophysiological correlates of these brain areas underlying non-literal processing remain underexplored.MethodsTo address this, we investigated patterns of intracranial EEG activity during non-literal processing by leveraging a unique patient population. Seven neurosurgical patients with invasive electrophysiological monitoring of superficial brain activity were recruited. Intracranial neural responses were recorded over the temporal-parietal junction (TPJ) and its surrounding areas while patients performed a language task. Participants listened to vignettes that ended with non-literal or literal statements and were then asked related questions to which they responded verbally.ResultsWe found differential neurophysiological activity during the processing of non-literal statements as compared to literal statements, especially in low-Gamma (30-70 Hz) and delta (1-4 Hz) bands. In addition, we found that neural responses related to non-literal processing in the high-gamma band (>70 Hz) were significantly more prominent at TPJ electrodes as compared to non-TPJ (i.e., control) electrodes in most subjects. Moreover, in half of patients, high-gamma activity related to non-literal processing was accompanied by delta-band modulation.ConclusionThese results suggest that both low- and high-frequency electrophysiological activities in the temporal-parietal junction play a crucial role during non-literal language processing in the human brain. The current investigation, utilizing better spatial and temporal resolution of human intracranial electrocorticography, provides a unique opportunity to gain insights into the localized brain dynamics of the TPJ during the processing of non-literal language expressions.

Dataset Information

Intracranial recordings show evidence of numerosity tuning in human parietal cortex.

Publications

Intracranial recordings show evidence of numerosity tuning in human parietal cortex.

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