Ontology highlight
ABSTRACT:
SUBMITTER: Reuschl AK
PROVIDER: S-EPMC9350556 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Reuschl Ann-Kathrin AK Mesner Dejan D Shivkumar Maitreyi M Whelan Matthew V X MVX Pallett Laura J LJ Guerra-Assunção José Afonso JA Madansein Rajhmun R Dullabh Kaylesh J KJ Sigal Alex A Thornhill John P JP Herrera Carolina C Fidler Sarah S Noursadeghi Mahdad M Maini Mala K MK Jolly Clare C
Cell reports 20220401 2
HIV-1 replicates in CD4<sup>+</sup> T cells, leading to AIDS. Determining how HIV-1 shapes its niche to create a permissive environment is central to informing efforts to limit pathogenesis, disturb reservoirs, and achieve a cure. A key roadblock in understanding HIV-T cell interactions is the requirement to activate T cells in vitro to make them permissive to infection. This dramatically alters T cell biology and virus-host interactions. Here we show that HIV-1 cell-to-cell spread permits effic ...[more]