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Recent advances in targeting protein kinases and pseudokinases in cancer biology.

ABSTRACT: Kinases still remain the most favorable members of the druggable genome, and there are an increasing number of kinase inhibitors approved by the FDA to treat a variety of cancers. Here, we summarize recent developments in targeting kinases and pseudokinases with some examples. Targeting the cell cycle machinery garnered significant clinical success, however, a large section of the kinome remains understudied. We also review recent developments in the understanding of pseudokinases and discuss approaches on how to effectively target in cancer.

SUBMITTER: Riegel K

PROVIDER: S-EPMC9354965 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Recent advances in targeting protein kinases and pseudokinases in cancer biology.

Riegel Kristina K Vijayarangakannan Parthiban P Kechagioglou Petros P Bogucka Katarzyna K Rajalingam Krishnaraj K

Frontiers in cell and developmental biology 20220722

Kinases still remain the most favorable members of the druggable genome, and there are an increasing number of kinase inhibitors approved by the FDA to treat a variety of cancers. Here, we summarize recent developments in targeting kinases and pseudokinases with some examples. Targeting the cell cycle machinery garnered significant clinical success, however, a large section of the kinome remains understudied. We also review recent developments in the understanding of pseudokinases and discuss ap ...[more]

PMID: 35938171

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