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Past experience shapes the neural circuits recruited for future learning.

ABSTRACT: Experimental research controls for past experience, yet prior experience influences how we learn. Here, we tested whether we could recruit a neural population that usually encodes rewards to encode aversive events. Specifically, we found that GABAergic neurons in the lateral hypothalamus (LH) were not involved in learning about fear in naïve rats. However, if these rats had prior experience with rewards, LH GABAergic neurons became important for learning about fear. Interestingly, inhibition of these neurons paradoxically enhanced learning about neutral sensory information, regardless of prior experience, suggesting that LH GABAergic neurons normally oppose learning about irrelevant information. These experiments suggest that prior experience shapes the neural circuits recruited for future learning in a highly specific manner, reopening the neural boundaries we have drawn for learning of particular types of information from work in naïve subjects.

SUBMITTER: Sharpe MJ

PROVIDER: S-EPMC9356300 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Past experience shapes the neural circuits recruited for future learning.

Sharpe Melissa J MJ Batchelor Hannah M HM Mueller Lauren E LE Gardner Matthew P H MPH Schoenbaum Geoffrey G

Nature neuroscience 20210215 3

Experimental research controls for past experience, yet prior experience influences how we learn. Here, we tested whether we could recruit a neural population that usually encodes rewards to encode aversive events. Specifically, we found that GABAergic neurons in the lateral hypothalamus (LH) were not involved in learning about fear in naïve rats. However, if these rats had prior experience with rewards, LH GABAergic neurons became important for learning about fear. Interestingly, inhibition of ...[more]

PMID: 33589832

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