Dataset Information

Association of Physical Activity With Bioactive Lipids and Cardiovascular Events.

ABSTRACT:

Background

To clarify the mechanisms underlying physical activity (PA)-related cardioprotection, we examined the association of PA with plasma bioactive lipids (BALs) and cardiovascular disease (CVD) events. We additionally performed genome-wide associations.

Methods

PA-bioactive lipid associations were examined in VITAL (VITamin D and OmegA-3 TriaL)-clinical translational science center (REGISTRATION: URL: https://www.

Clinicaltrials

gov; Unique identifier: NCT01169259; N=1032) and validated in JUPITER (Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin)-NC (REGISTRATION: URL: https://www.

Clinicaltrials

gov; Unique identifier: NCT00239681; N=589), using linear models adjusted for age, sex, race, low-density lipoprotein-cholesterol, total-C, and smoking. Significant BALs were carried over to examine associations with incident CVD in 2 nested CVD case-control studies: VITAL-CVD (741 case-control pairs) and JUPITER-CVD (415 case-control pairs; validation).

Results

We detected 145 PA-bioactive lipid validated associations (false discovery rate <0.1). Annotations were found for 6 of these BALs: 12,13-diHOME, 9,10-diHOME, lysoPC(15:0), oxymorphone-3b-D-glucuronide, cortisone, and oleoyl-glycerol. Genetic analysis within JUPITER-NC showed associations of 32 PA-related BALs with 22 single-nucleotide polymorphisms. From PA-related BALs, 12 are associated with CVD.

Conclusions

We identified a PA-related bioactive lipidome profile out of which 12 BALs also had opposite associations with incident CVD events.

SUBMITTER: Hoshi RA

PROVIDER: S-EPMC9357171 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association of Physical Activity With Bioactive Lipids and Cardiovascular Events.

Hoshi Rosangela A RA Liu Yanyan Y Luttmann-Gibson Heike H Tiwari Saumya S Giulianini Franco F Andres Allen M AM Watrous Jeramie D JD Cook Nancy R NR Costenbader Karen H KH Okereke Olivia I OI Ridker Paul M PM Manson JoAnn E JE Lee I-Min IM Vinayagamoorthy Manickavasagar M Cheng Susan S Copeland Trisha T Jain Mohit M Chasman Daniel I DI Demler Olga V OV Mora Samia S

Circulation research 20220719 4

<h4>Background</h4>To clarify the mechanisms underlying physical activity (PA)-related cardioprotection, we examined the association of PA with plasma bioactive lipids (BALs) and cardiovascular disease (CVD) events. We additionally performed genome-wide associations.<h4>Methods</h4>PA-bioactive lipid associations were examined in VITAL (VITamin D and OmegA-3 TriaL)-clinical translational science center (REGISTRATION: URL: https://www.<h4>Clinicaltrials</h4>gov; Unique identifier: NCT01169259; N= ...[more]

PMID: 35862024

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Dataset Information

Association of Physical Activity With Bioactive Lipids and Cardiovascular Events.

Background

Methods

Clinicaltrials

Clinicaltrials

Results

Conclusions

Publications

Association of Physical Activity With Bioactive Lipids and Cardiovascular Events.

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