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Structure and dynamic regulation of Src-family kinases.

ABSTRACT: Src-family kinases are modular signaling proteins involved in a diverse array of cellular processes. All members of the Src family share the same domain organization, with modular SH3, SH2 and kinase domains followed by a C-terminal negative regulatory tail. X-ray crystallographic analyses of several Src family members have revealed critical roles for the SH3 and SH2 domains in the down-regulation of the kinase domain. This review focuses on biological, biophysical, and computational studies that reveal conformationally distinct active states within this unique kinase family.

SUBMITTER: Engen JR

PROVIDER: S-EPMC9357288 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature

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Structure and dynamic regulation of Src-family kinases.

Engen J R JR Wales T E TE Hochrein J M JM Meyn M A MA Banu Ozkan S S Bahar I I Smithgall T E TE

Cellular and molecular life sciences : CMLS 20081001 19

Src-family kinases are modular signaling proteins involved in a diverse array of cellular processes. All members of the Src family share the same domain organization, with modular SH3, SH2 and kinase domains followed by a C-terminal negative regulatory tail. X-ray crystallographic analyses of several Src family members have revealed critical roles for the SH3 and SH2 domains in the down-regulation of the kinase domain. This review focuses on biological, biophysical, and computational studies tha ...[more]

PMID: 18563293

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SRC family kinases are involved in the regulation of CD20

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