Ontology highlight
ABSTRACT:
SUBMITTER: Aigrot MS
PROVIDER: S-EPMC9358396 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Aigrot Marie-Stéphane MS Barthelemy Clara C Moyon Sarah S Dufayet-Chaffaud Gaelle G Izagirre-Urizar Leire L Gillet-Legrand Beatrix B Tada Satoru S Bayón-Cordero Laura L Chara Juan-Carlos JC Matute Carlos C Cartier Nathalie N Lubetzki Catherine C Tepavčević Vanja V
EMBO molecular medicine 20220713 8
Preventing neurodegeneration-associated disability progression in patients with multiple sclerosis (MS) remains an unmet therapeutic need. As remyelination prevents axonal degeneration, promoting this process in patients might enhance neuroprotection. In demyelinating mouse lesions, local overexpression of semaphorin 3F (Sema3F), an oligodendrocyte progenitor cell (OPC) attractant, increases remyelination. However, molecular targeting to MS lesions is a challenge. A clinically relevant paradigm ...[more]