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Influenza vaccination and mortality among adults with heart failure in an integrated healthcare delivery system, 2009-2018.


ABSTRACT:

Background

Influenza infection can result in decompensation or exacerbation of heart failure (HF) symptoms, hospitalization, and death.

Objective

To examine the association of influenza vaccination with mortality and hospitalization during influenza and non-influenza seasons between 2009 and 2018.

Design, setting, and participants

In this prospective, observational cohort study, we included Kaiser Permanente Southern California members with a HF diagnosis prior to September 1 each year from 2009 to 2017.

Exposure

The first influenza vaccination in each season (September 1 to May 31) was recorded. Vaccinated/unvaccinated patients were matched 1:1 on age, sex, and ejection fraction at the vaccination date (n-total = 74,870).

Main outcomes

Patients were followed through the end of each influenza season for all-cause mortality. Secondary outcomes included cardiovascular mortality and all-cause hospitalization. In a sensitivity analysis, we examined mortality in the non-influenza season.

Results

Influenza vaccinated vs unvaccinated patients had more comorbidities and higher healthcare utilization. After multivariable adjustment for utilization, sociodemographics, comorbidities, and medications, influenza vaccinated vs unvaccinated patients had a lower risk of all-cause mortality and cardiovascular mortality during the influenza season (hazard ratio [HR] 0.66, 95% confidence interval [CI] 0.63, 0.70 and HR 0.68, 95% CI 0.63, 0.74, respectively) but a higher risk of all-cause hospitalization (HR 1.27, 95% CI 1.21, 1.31). There was no association between influenza vaccination and all-cause or cardiovascular mortality during the non-influenza season (HR 0.99, 95% CI 0.89, 1.09 and HR 1.00, 95% CI 0.84, 1.21, respectively).

Conclusions

Influenza vaccination in HF patients was associated with a lower risk of mortality during the influenza season. Our findings provide support for recommendations of universal influenza vaccination in patients with HF.

SUBMITTER: Mefford MT 

PROVIDER: S-EPMC9360203 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Publications

Influenza vaccination and mortality among adults with heart failure in an integrated healthcare delivery system, 2009-2018.

Mefford Matthew T MT   Liu Ran R   Bruxvoort Katia K   Qian Lei L   Doris Jonathan M JM   Koyama Sandra Y SY   Tseng Hung Fu HF   Reynolds Kristi K  

Journal of general internal medicine 20210811 10


<h4>Background</h4>Influenza infection can result in decompensation or exacerbation of heart failure (HF) symptoms, hospitalization, and death.<h4>Objective</h4>To examine the association of influenza vaccination with mortality and hospitalization during influenza and non-influenza seasons between 2009 and 2018.<h4>Design, setting, and participants</h4>In this prospective, observational cohort study, we included Kaiser Permanente Southern California members with a HF diagnosis prior to September  ...[more]

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