Unknown

Dataset Information

0

MBD1/HDAC3-miR-5701-FGFR2 axis promotes the development of gastric cancer.


ABSTRACT: Gastric cancer (GC) remains one of the leading causes of cancer-related deaths worldwide due to the lack of specific biomarkers for the early diagnosis and universal accepted therapy for advanced GC. Lower levels of miR-5701 were found in the GC tissue from the online sequencing data and confirmed in the GC tissues and GC cell lines. Overexpression of miR-5701 inhibited the proliferation and migration of GC cells and promoted the apoptosis of these cells. Bioinformatics analyses and luciferase assay showed that miR-5701 targeted FGFR2, which acted as an oncogene in GC. Nude mice with GC cells overexpressing miR-5701 exhibited smaller tumor sizes and less lung metastases. The miR-5701 expression was directly, transcriptionally inhibited by MBD1 together with HDAC3 by binding together to form a complex. Knocked down MBD1 or HDAC3 increased the miR-5701 expression. These results indicated the potential use of exogenously administered miR-5701 or agents that elevated endogenous miR-5701 to inhibit GC, improving the prognosis of patients with GC.

SUBMITTER: Zhao C 

PROVIDER: S-EPMC9365560 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

MBD1/HDAC3-miR-5701-FGFR2 axis promotes the development of gastric cancer.

Zhao Changan C   Miao Jiyu J   Sun Ruifang R   Liang Rui R   Chen Wenhu W   Gao Yi Y   Wang Xiaofei X   Han Shuiping S   Zhao Wenbao W   Lei Ting T   Huang Chen C  

Aging 20220722 14


Gastric cancer (GC) remains one of the leading causes of cancer-related deaths worldwide due to the lack of specific biomarkers for the early diagnosis and universal accepted therapy for advanced GC. Lower levels of miR-5701 were found in the GC tissue from the online sequencing data and confirmed in the GC tissues and GC cell lines. Overexpression of miR-5701 inhibited the proliferation and migration of GC cells and promoted the apoptosis of these cells. Bioinformatics analyses and luciferase a  ...[more]

Similar Datasets

| S-EPMC8299726 | biostudies-literature
| S-EPMC8969178 | biostudies-literature
| S-EPMC10123001 | biostudies-literature
| S-EPMC7731483 | biostudies-literature
| S-EPMC6432638 | biostudies-literature
| S-EPMC6249325 | biostudies-literature
| S-EPMC7306839 | biostudies-literature
| S-EPMC9851253 | biostudies-literature
| S-EPMC9037572 | biostudies-literature
| S-EPMC6704702 | biostudies-literature