Ontology highlight
ABSTRACT:
SUBMITTER: Michely J
PROVIDER: S-EPMC9374781 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Michely Jochen J Eldar Eran E Erdman Alon A Martin Ingrid M IM Dolan Raymond J RJ
Communications biology 20220812 1
Instrumental learning is driven by a history of outcome success and failure. Here, we examined the impact of serotonin on learning from positive and negative outcomes. Healthy human volunteers were assessed twice, once after acute (single-dose), and once after prolonged (week-long) daily administration of the SSRI citalopram or placebo. Using computational modelling, we show that prolonged boosting of serotonin enhances learning from punishment and reduces learning from reward. This valence-depe ...[more]