Transcriptional regulation by a RecQ helicase.
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ABSTRACT:
SUBMITTER: Debnath S
PROVIDER: S-EPMC9379128 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Transcriptional regulation by a RecQ helicase.
Debnath Subrata S Lu Xing X Sharma Sudha S
Methods in enzymology 20220418
RecQ helicases participate in a variety of DNA metabolic processes through their multiple biochemical activities. In vitro characterization and cellular studies have suggested that RECQ1 (also known as RECQL or RECQL1) performs its diverse functions through specific interactions with DNA and protein partners. We have taken an unbiased approach to determine the contribution of RECQ1 in genome maintenance and as a putative susceptibility factor in breast cancer. Here, we provide methodology to map ...[more]
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