Dataset Information

Serum adiponectin-levels are predictive of probable posttraumatic stress disorder in women.

ABSTRACT:

Background

Accumulative evidence indicates a role for adiponectin, a polypeptide secreted by adipose tissue, in the pathophysiology of posttraumatic disorder (PTSD) via metabolic and inflammatory pathways. This study examined adiponectin as a potential predictive biomarker for PTSD among female rape survivors.

Methods

We evaluated the relationship of baseline serum adiponectin levels to the development of probable PTSD at 3- and 6-months post rape-exposure and compared adiponectin levels between 542 rape-exposed (RE) and 593 rape-unexposed women (RUE). Probable PTSD were defined as Davidson Trauma Scale score ≥40. Data were analysed using multivariate regression models and a generalized estimating equation (GEE) model. We adjusted for clinically relevant covariates associated with PTSD, as well as adiposity indices.

Results

Participants who were in the mid-and high adiponectin tertile groups versus the lowest tertile group had a significantly reduced risk of probable PTSD among at 6 months follow-up, independent of adiposity(aOR = 0.45[0.22-1.05], p = 0.035; aOR = 0.44[0.22-0.90], p = 0.024). However, there was no effect of group (RE vs. RUE).

Limitations

Adiponectin assays were conducted on non-fasting blood samples and information on chronic medication, dietary factors and levels of physical activity were not collected. There was a high attrition rate among rape exposed participants.

Conclusions

Our results show that higher serum adiponectin levels are associated with reduced risk of probable PTSD over a 6-month period. This finding supports the hypothesis that serum adiponectin is a potential risk biomarker for PTSD.

SUBMITTER: Vuong E

PROVIDER: S-EPMC9379978 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Publications

Serum adiponectin-levels are predictive of probable posttraumatic stress disorder in women.

Vuong Eileen E Mhlongo Shibe S Chirwa Esnat E Lombard Carl C Peer Nasheeta N Hemmings Sian Megan SM Abrahams Naeemah N Seedat Soraya S

Neurobiology of stress 20220808

<h4>Background</h4>Accumulative evidence indicates a role for adiponectin, a polypeptide secreted by adipose tissue, in the pathophysiology of posttraumatic disorder (PTSD) via metabolic and inflammatory pathways. This study examined adiponectin as a potential predictive biomarker for PTSD among female rape survivors.<h4>Methods</h4>We evaluated the relationship of baseline serum adiponectin levels to the development of probable PTSD at 3- and 6-months post rape-exposure and compared adiponectin ...[more]

PMID: 35982731

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Dataset Information

Serum adiponectin-levels are predictive of probable posttraumatic stress disorder in women.

Background

Methods

Results

Limitations

Conclusions

Publications

Serum adiponectin-levels are predictive of probable posttraumatic stress disorder in women.

Similar Datasets

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