Dataset Information

Memory B cell development after asymptomatic or mild symptomatic SARS-CoV-2 infection.

ABSTRACT:

Background

The development of memory B cells after asymptomatic SARS-CoV-2 infection is not well understood.

Methods

We compared Spike antibody titers, pseudovirus neutralizing antibody titers, and memory B cell responses among SARS-CoV-2 PCR positive Marine recruits who either reported asymptomatic or symptomatic infection.

Results

36 asymptomatic participants exhibited similar Spike IgG titers, Spike IgA titers, and pseudovirus neutralization titers compared to 30 symptomatic participants. Pseudovirus neutralization and Spike IgG titers showed significant positive correlations with frequency of memory B cells.

Conclusions

Among young adults, asymptomatic SARS-CoV-2 infection induced antibody and memory B cell responses comparable to mild symptomatic infection.

SUBMITTER: Kato Y

PROVIDER: S-EPMC9384564 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Publications

Memory B-Cell Development After Asymptomatic or Mild Symptomatic SARS-CoV-2 Infection.

Kato Yu Y Bloom Nathaniel I NI Sun Peifang P Balinsky Corey A CA Qiu Qi Q Cheng Ying Y Jani Vihasi V Schilling Megan A MA Goforth Carl W CW Weir Dawn L DL Ramos Irene I Sealfon Stuart C SC Letizia Andrew G AG Crotty Shane S

The Journal of infectious diseases 20221201 1

<h4>Background</h4>The development of memory B cells after asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is not well understood.<h4>Methods</h4>We compared spike antibody titers, pseudovirus neutralizing antibody titers, and memory B-cell responses among SARS-CoV-2 PCR-positive Marine recruits who either reported asymptomatic or symptomatic infection.<h4>Results</h4>Thirty-six asymptomatic participants exhibited similar spike IgG titers, spike IgA titers, an ...[more]

PMID: 35892131

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