Dataset Information

Targeted therapy in Coronavirus disease 2019 (COVID-19): Implication from cell and gene therapy to immunotherapy and vaccine.

ABSTRACT: Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) is a highly pathogenic and transmissible virus. Infection caused by SARS-CoV-2 known as Coronavirus disease 2019 (COVID-19) can be severe, especially among high risk populations affected of underlying medical conditions. COVID-19 is characterized by the severe acute respiratory syndrome, a hyper inflammatory syndrome, vascular injury, microangiopathy and thrombosis. Antiviral drugs and immune modulating methods has been evaluated. So far, a particular therapeutic option has not been approved for COVID-19 and a variety of treatments have been studied for COVID-19 including, current treatment such as oxygen therapy, corticosteroids, antiviral agents until targeted therapy and vaccines which are diverse in each patient and have various outcomes. According to the findings of different in vitro and in vivo studies, some novel approach such as gene editing, cell based therapy, and immunotherapy may have significant potential in the treatment of COVID-19. Based on these findings, this paper aims to review the different strategies of treatment against COVID-19 and provide a summary from traditional and newer methods in curing COVID-19.

SUBMITTER: Shirzad M

PROVIDER: S-EPMC9385778 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Targeted therapy in Coronavirus disease 2019 (COVID-19): Implication from cell and gene therapy to immunotherapy and vaccine.

Shirzad Moein M Nourigorji Marjan M Sajedi Atefe A Ranjbar Maryam M Rasti Faeze F Sourani Zahra Z Moradi Mona M Mostafa Mir Seyed S Memar Mohammad Yousef MY

International immunopharmacology 20220818

Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) is a highly pathogenic and transmissible virus. Infection caused by SARS-CoV-2 known as Coronavirus disease 2019 (COVID-19) can be severe, especially among high risk populations affected of underlying medical conditions. COVID-19 is characterized by the severe acute respiratory syndrome, a hyper inflammatory syndrome, vascular injury, microangiopathy and thrombosis. Antiviral drugs and immune modulating methods has been evaluated. So f ...[more]

PMID: 35998506

Similar Datasets

Project description:Coronavirus disease 2019 (COVID-19), beginning in December 2019, has spread worldwide, leading to the death of millions. Owing to the absence of definitive treatment, vaccination against COVID-19 emerged as an effective strategy against the spread of the pandemic. Acceptance of the COVID-19 vaccine has advanced considerably, and vaccine-related research has significantly increased over the past three years. This study aimed to evaluate the content and external characteristics of COVID-19 vaccine-related literature for tracking research trends related to the global COVID-19 vaccine with the means of bibliometrics and visualization maps. A total of 18,285 records in 3499 journals were retrieved in the Web of Science Core Collection database and included in the final analysis. China was the first to focus on COVID-19 vaccine research, while European and American countries started late but developed rapidly. The USA and the UK are the top contributors to COVID-19 vaccine development, with the largest number of publications. The University of Washington and Harvard Medical School were the leading institutions, while Krammer, F. from Icahn School of Medicine at Mount Sinai was the author most active and influential to the topic. The New England Journal of Medicine had the highest number of citations and the highest TLS, and was the most cited and influential journal in the field of COVID-19 vaccine research. COVID-19 vaccine research topics and hotspots focused on populations' attitudes towards vaccination, immunity-related information analysis of spike proteins, the effectiveness and side effects of the COVID-19 vaccine, and the public management of epidemic transmission. The findings of this study provide the global status, research hotspots and potential trends in the field of COVID-19 vaccine research, which will assist researchers in mastering the knowledge structure, and evaluating and guiding future developmental directions of COVID-19 vaccine.

Project description:IntroductionCoronavirus disease 2019 (COVID-19) vaccine hesitancy is a complex health challenge characterized by a delay in the acceptance or refusal of the vaccination with context-specific determinants. Our study, therefore, assessed the COVID-19 vaccine acceptance among urban dwellers in the Central Region, of Ghana.MethodsA cross sectional study was conducted between September and November, 2022 using a multi-stage cluster sampling procedure among 377 participants. A modified World Health Organization pretested paper-based questionnaire was administered to study participants. The data was analyzed using Statistical Package for Social Sciences (SPSS) version 26. Descriptive and inferential statistics were carried out and results were summarized into frequencies, percentages, tables, and charts for clarity. A conventional p-value < 0.05 was considered statistically significant.ResultsThe study revealed that COVID-19 vaccine acceptance was 20.0% (76/377) and vaccine hesitancy was 80.0% (301/377). Out of the 377 participants, their socio-demographic characteristics showed that the majority were below 25 years 53.8% (203/377), [vaccine acceptance; 36.84% (28/76) vs vaccine hesitancy; 58.14% (175/301)], and females 50.1% (189/377), [vaccine acceptance; 56.58% (43/76) vs vaccine hesitancy; 48.50% (146/301)]. Common reasons for COVID-19 vaccine hesitancy included mistrust of the source of the vaccine, personal belief and experience, mistrust of the drug development process, mistrust in the health system, and mistrust of the pharmaceutical company. Age above 25 years, female, educational levels, senior high school and above, being employed, and hearing of new vaccine had a significance influence on COVID-19 vaccine acceptance.ConclusionCOVID-19 vaccine acceptance was low with high vaccine hesitancy among participants. The study's findings highlights the importance of addressing vaccine hesitancy through building trust in the vaccine development processes, including the provision of accurate information about the vaccine safety and efficacy. Resolving concerns related to the source of the vaccine and the overall healthcare system are important to address vaccine hesitancy. Policy makers could adopt tailored interventions targeting specific demographic groups, such as the younger population and females to increase vaccine acceptance. Ghana's public health authorities could adopt the findings to re-strategize its urban COVID-19 vaccine campaigns to address misconceptions and misinformation to increase vaccine acceptance.

Dataset Information

Targeted therapy in Coronavirus disease 2019 (COVID-19): Implication from cell and gene therapy to immunotherapy and vaccine.

Publications

Targeted therapy in Coronavirus disease 2019 (COVID-19): Implication from cell and gene therapy to immunotherapy and vaccine.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets