Dataset Information

Multi-center matched cohort study of convalescent plasma for hospitalized patients with COVID-19.

ABSTRACT:

Background

Although frequently used in the early pandemic, data on the effectiveness of COVID-19 convalescent plasma (CCP) remain mixed. We investigated the effectiveness and safety of CCP in hospitalized COVID-19 patients in real-world practices during the first two waves of the pandemic in a multi-hospital healthcare system in Texas.

Methods and findings

Among 11,322 hospitalized patients with confirmed COVID-19 infection from July 1, 2020 to April 15, 2021, we included patients who received CCP and matched them with those who did not receive CCP within ±2 days of the transfusion date across sites within strata of sex, age groups, days and use of dexamethasone from hospital admission to the match date, and oxygen requirements 4-12 hours prior to the match date. Cox proportional hazards model estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for effectiveness outcomes in a propensity score 1:1 matched cohort. Pre-defined safety outcomes were described. We included 1,245 patients each in the CCP treated and untreated groups. Oxygen support was required by 93% of patients at the baseline. The pre-defined primary effectiveness outcome of 28-day in-hospital all-cause mortality (HR = 0.85; 95%CI: 0.66,1.10) were similar between treatment groups. Sensitivity and stratified analyses found similar null results. CCP-treated patients were less likely to be discharged alive (HR = 0.82; 95%CI: 0.74, 0.91), and more likely to receive mechanical ventilation (HR = 1.48; 95%CI: 1.12, 1.96). Safety outcomes were rare and similar between treatment groups.

Conclusion

The findings in this large, matched cohort of patients hospitalized with COVID-19 and mostly requiring oxygen support at the time of treatment, do not support a clinical benefit in 28-day in-hospital all-cause mortality for CCP. Future studies should assess the potential benefits with specifically high-titer units in perhaps certain subgroups of patients (e.g. those with early disease or immunocompromised).

SUBMITTER: Zhou CK

PROVIDER: S-EPMC9387784 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Multi-center matched cohort study of convalescent plasma for hospitalized patients with COVID-19.

Zhou Cindy Ke CK Bennett Monica M MM Villa Carlos H CH Hammonds Kendall P KP Lu Yun Y Ettlinger Jason J Priest Elisa L EL Gottlieb Robert L RL Davis Steven S Mays Edward E Clarke Tainya C TC Shoaibi Azadeh A Wong Hui-Lee HL Anderson Steven A SA Kelly Ronan J RJ

PloS one 20220818 8

<h4>Background</h4>Although frequently used in the early pandemic, data on the effectiveness of COVID-19 convalescent plasma (CCP) remain mixed. We investigated the effectiveness and safety of CCP in hospitalized COVID-19 patients in real-world practices during the first two waves of the pandemic in a multi-hospital healthcare system in Texas.<h4>Methods and findings</h4>Among 11,322 hospitalized patients with confirmed COVID-19 infection from July 1, 2020 to April 15, 2021, we included patients ...[more]

PMID: 35980913

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Dataset Information

Multi-center matched cohort study of convalescent plasma for hospitalized patients with COVID-19.

Background

Methods and findings

Conclusion

Publications

Multi-center matched cohort study of convalescent plasma for hospitalized patients with COVID-19.

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