Ontology highlight
ABSTRACT:
SUBMITTER: Henkin G
PROVIDER: S-EPMC9388136 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Henkin Gil G Chew Wei-Xiang WX Nédélec François F Surrey Thomas T
Proceedings of the National Academy of Sciences of the United States of America 20220812 33
During cell division, cross-linking motors determine the architecture of the spindle, a dynamic microtubule network that segregates the chromosomes in eukaryotes. It is unclear how motors with opposite directionality coordinate to drive both contractile and extensile behaviors in the spindle. Particularly, the impact of different cross-linker designs on network self-organization is not understood, limiting our understanding of self-organizing structures in cells but also our ability to engineer ...[more]