Ontology highlight
ABSTRACT:
SUBMITTER: Phan A
PROVIDER: S-EPMC9389596 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Phan Amber A Romeis Emily E Tantalo Lauren L Giacani Lorenzo L
Current protocols 20220801 8
Although the isolation of Treponema pallidum subsp. pallidum (T. pallidum) from a syphilis patient dates to 1912, for the duration of the 20<sup>th</sup> century, this pathogen has remained an exceedingly difficult organism to study due to the lack of a system to support its viability in vitro. This limitation, in turn, has precluded the application of genetic engineering techniques via transformation and subsequent selection of T. pallidum transformants. A recently described method for in vitro ...[more]