Ontology highlight
ABSTRACT:
SUBMITTER: Callegari E
PROVIDER: S-EPMC9395755 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Callegari Elisa E Guerriero Paola P Bassi Cristian C D'Abundo Lucilla L Frassoldati Antonio A Simoni Edi E Astolfi Laura L Silini Enrico Maria EM Sabbioni Silvia S Negrini Massimo M
Molecular therapy. Nucleic acids 20220720
Palbociclib is in early-stage clinical testing in advanced hepatocellular carcinoma (HCC). Here, we investigated whether the anti-tumor activity of palbociclib, which prevents the CDK4/6-mediated phosphorylation of RB1 but simultaneously activates AKT signaling, could be improved by its combination with a PI3K/AKT/mTOR inhibitor in liver cancer models. The selective pan-AKT inhibitor, MK-2206, or the microRNA-199a-3p were tested in combination with palbociclib in HCC cell lines and in the TG221 ...[more]