Doxorubicin-induced cardiotoxicity is mediated by neutrophils through release of neutrophil elastase.
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ABSTRACT:
SUBMITTER: Bhagat A
PROVIDER: S-EPMC9400062 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
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Doxorubicin-induced cardiotoxicity is mediated by neutrophils through release of neutrophil elastase.
Bhagat Anchit A Shrestha Pradeep P Jeyabal Prince P Peng Zhanglong Z Watowich Stephanie S SS Kleinerman Eugenie S ES
Frontiers in oncology 20220810
The mechanisms by which Doxorubicin (Dox) causes acute and late cardiotoxicity are not completely understood. One understudied area is the innate immune response, and in particular the role of neutrophils in Dox-induced cardiotoxicity. Here, using echocardiography, flow cytometry and immunofluorescence staining, we demonstrated increased infiltration of neutrophils that correlated with decreased heart function, disruption of vascular structures and increased collagen deposition in the heart afte ...[more]
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