DsbA is required for stable expression of outer membrane protein YscC and for efficient Yop secretion in Yersinia pestis.
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ABSTRACT:
SUBMITTER: Jackson MW
PROVIDER: S-EPMC94010 | biostudies-literature | 1999 Aug
REPOSITORIES: biostudies-literature
Publications
DsbA is required for stable expression of outer membrane protein YscC and for efficient Yop secretion in Yersinia pestis.
Journal of bacteriology 19990801 16
The role of the periplasmic disulfide oxidoreductase DsbA in Yop secretion was investigated in Yersinia pestis. A Y. pestis dsbA mutant secreted reduced amounts of the V antigen and Yops and expressed reduced amounts of the full-sized YscC protein. Site-directed mutagenesis of the four cysteine residues present in the YscC protein resulted in defects similar to those found in the dsbA mutant. These results suggest that YscC contains at least one disulfide bond that is essential for the function ...[more]
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