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Para-Fluorination of Anilides Using Electrochemically Generated Hypervalent Iodoarenes.

ABSTRACT: The para-selective fluorination reaction of anilides using electrochemically generated hypervalent ArIF₂ is reported, with Et₃ N ⋅ 5HF serving as fluoride source and as supporting electrolyte. This electrochemical reaction is characterized by a simple set-up, easy scalability and affords a broad variety of fluorinated anilides from easily accessible anilides in good yields up to 86 %.

SUBMITTER: Berger M

PROVIDER: S-EPMC9401020 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Para-Fluorination of Anilides Using Electrochemically Generated Hypervalent Iodoarenes.

Berger Michael M Lenhard Marola S MS Waldvogel Siegfried R SR

Chemistry (Weinheim an der Bergstrasse, Germany) 20220607 41

The para-selective fluorination reaction of anilides using electrochemically generated hypervalent ArIF2 is reported, with Et3 N ⋅ 5HF serving as fluoride source and as supporting electrolyte. This electrochemical reaction is characterized by a simple set-up, easy scalability and affords a broad variety of fluorinated anilides from easily accessible anilides in good yields up to 86 %. ...[more]

PMID: 35510825

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