Unknown

Dataset Information

0

The Prognostic Value of Eight Immunohistochemical Markers Expressed in the Tumor Microenvironment and on Hodgkin Reed-Sternberg Cells in Pediatric Patients With Classical Hodgkin Lymphoma.

ABSTRACT: Immunohistochemical markers are associated with treatment outcome in adults with classical Hodgkin Lymphoma (cHL). Studies in children are scarce and inconsistent. We investigated in 67 children with cHL, whether the expression of CD15, CD30, PAX5, PD-1, PD-L1, CD68, CD163 and TARC at diagnosis is associated with disease free survival (DFS) and with interim remission status. Low CD15 and low TARC expression were associated with relapsed disease. Low expression of PD-L1 was associated with complete remission at interim PET-scan. Our data suggest a difference between pediatric and adult cHL. This underlines the importance of future research into specific prognostic factors in pediatric cHL, indispensable for improvement of treatment in this population.

SUBMITTER: Zijtregtop EAM 

PROVIDER: S-EPMC9402887 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

The Prognostic Value of Eight Immunohistochemical Markers Expressed in the Tumor Microenvironment and on Hodgkin Reed-Sternberg Cells in Pediatric Patients With Classical Hodgkin Lymphoma.

Zijtregtop Eline A M EAM   Tromp Ilse I   Dandis Rana R   Zwaan Christian M CM   Lam King H KH   Meyer-Wentrup Friederike A G FAG   Beishuizen Auke A  

Pathology oncology research : POR 20220811

Immunohistochemical markers are associated with treatment outcome in adults with classical Hodgkin Lymphoma (cHL). Studies in children are scarce and inconsistent. We investigated in 67 children with cHL, whether the expression of CD15, CD30, PAX5, PD-1, PD-L1, CD68, CD163 and TARC at diagnosis is associated with disease free survival (DFS) and with interim remission status. Low CD15 and low TARC expression were associated with relapsed disease. Low expression of PD-L1 was associated with comple  ...[more]

Similar Datasets

Unknown Tackling the dysregulated immune-checkpoints in classical Hodgkin lymphoma: bidirectional regulations between the microenvironment and Hodgkin/Reed-Sternberg cells.
| S-EPMC10244642 | biostudies-literature
Unknown Hodgkin Reed-Sternberg-Like Cells in Non-Hodgkin Lymphoma.
| S-EPMC7760963 | biostudies-literature
Unknown Multiplexed Spatial Profiling of Hodgkin Reed-Sternberg Cell Neighborhoods in Classic Hodgkin Lymphoma.
| S-EPMC11369618 | biostudies-literature
Unknown The AP1-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphoma.
| S-EPMC1936978 | biostudies-literature
Transcriptomics Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma
2012-09-17 | E-GEOD-40160 | biostudies-arrayexpress
Transcriptomics Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma
2012-09-17 | GSE40160 | GEO
Unknown Hodgkin-Reed-Sternberg cells in classical Hodgkin lymphoma show alterations of genes encoding the NADPH oxidase complex and impaired reactive oxygen species synthesis capacity.
| S-EPMC3871653 | biostudies-literature
Unknown Molecular Evolution of Classic Hodgkin Lymphoma Revealed Through Whole-Genome Sequencing of Hodgkin and Reed Sternberg Cells.
| S-EPMC10150291 | biostudies-literature
Unknown Occurrence of minimal change nephrotic syndrome in classical Hodgkin lymphoma is closely related to the induction of c-mip in Hodgkin-Reed Sternberg cells and podocytes.
| S-EPMC2890576 | biostudies-literature
Unknown New molecular targets in Hodgkin and Reed-Sternberg cells.
| S-EPMC10230546 | biostudies-literature