Ontology highlight
ABSTRACT:
SUBMITTER: Ruan W
PROVIDER: S-EPMC9405579 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Ruan Wei W Ma Xinxin X Bang In Hyuk IH Liang Yafen Y Muehlschlegel Jochen Daniel JD Tsai Kuang-Lei KL Mills Tingting W TW Yuan Xiaoyi X Eltzschig Holger K HK
Biomedicines 20220810 8
Despite increasing availability and more successful interventional approaches to restore coronary reperfusion, myocardial ischemia-reperfusion injury is a substantial cause of morbidity and mortality worldwide. During myocardial ischemia, the myocardium becomes profoundly hypoxic, thus causing stabilization of hypoxia-inducible transcription factors (HIF). Stabilization of HIF leads to a transcriptional program that promotes adaptation to hypoxia and cellular survival. Transcriptional consequenc ...[more]