Ontology highlight
ABSTRACT:
SUBMITTER: Lucot KL
PROVIDER: S-EPMC9413527 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Lucot Katherine L KL Bukhari Syed A SA Webber Ebony D ED Bonham T Adam TA Darian-Smith Corinna C Montine Thomas J TJ Green Sherril L SL
Comparative medicine 20220726 4
Age-associated neurodegenerative changes, including amyloid β (Aβ) plaques, neurofibrillary tangles (NFTs), and amyloid angiopathy comparable to those seen in the brains of human patients with Alzheimer's disease (AD), have been reported in the brains of aged bears. However, the significance of these findings in bears is unclear due to the difficulty in assessing cognitive impairment and the lack of standardized approaches for the semiquantitative evaluation of Aβ plaques and NFTs. In this study ...[more]