Identification and disruption of lisRK, a genetic locus encoding a two-component signal transduction system involved in stress tolerance and virulence in Listeria monocytogenes.
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ABSTRACT:
SUBMITTER: Cotter PD
PROVIDER: S-EPMC94153 | biostudies-literature | 1999 Nov
REPOSITORIES: biostudies-literature
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Identification and disruption of lisRK, a genetic locus encoding a two-component signal transduction system involved in stress tolerance and virulence in Listeria monocytogenes.
Cotter P D PD Emerson N N Gahan C G CG Hill C C
Journal of bacteriology 19991101 21
lisRK encodes a two-component regulatory system in the food pathogen Listeria monocytogenes LO28. Following identification of the operon in an acid-tolerant Tn917 mutant, a deletion in the histidine kinase component was shown to result in a growth phase variation in acid tolerance, an ability to grow in high ethanol concentrations, and a significant reduction in virulence. ...[more]
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