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ABSTRACT:
SUBMITTER: Peklar B
PROVIDER: S-EPMC9415664 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Pharmaceutics 20220806 8
Glasdegib is a recently approved drug for the treatment of acute myeloid leukemia. It is formulated and marketed in monomaleate salt form. In our investigation, we were able to prepare a glasdegib dimaleate form, which could, in theory, exist in double-salt form or as a mixture of salt and co-crystal species. Therefore, the obtained crystals of glasdegib dimaleate were characterized via <sup>15</sup>N ssNMR and single-crystal X-ray diffraction, which revealed that the obtained glasdegib dimaleat ...[more]