Ontology highlight
ABSTRACT:
SUBMITTER: Cho J
PROVIDER: S-EPMC9418190 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Cho Jaeyong J Miyagawa Atsushi A Yamaguchi Kazuki K Abe Wakana W Tsugawa Yoji Y Tsugawa Yoji Y Yamamura Hatsuo H Imai Takeshi T
Scientific reports 20220826 1
Insulin secretion is regulated in multiple steps, and one of the main steps is in the endoplasmic reticulum (ER). Here, we show that UDP-glucose induces proinsulin ubiquitination by cereblon, and uridine binds and competes for proinsulin degradation and behaves as sustainable insulin secretagogue. Using insulin mutagenesis of neonatal diabetes variant-C43G and maturity-onset diabetes of the young 10 (MODY10) variant-R46Q, UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1) protects cereblon-d ...[more]