Ontology highlight
ABSTRACT:
SUBMITTER: Pal D
PROVIDER: S-EPMC9418860 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Pal Deepali D Blair Helen H Parker Jessica J Hockney Sean S Beckett Melanie M Singh Mankaran M Tirtakusuma Ricky R Nelson Ryan R McNeill Hesta H Angel Sharon H SH Wilson Aaron A Nizami Salem S Nakjang Sirintra S Zhou Peixun P Schwab Claire C Sinclair Paul P Russell Lisa J LJ Coxhead Jonathan J Halsey Christina C Allan James M JM Harrison Christine J CJ Moorman Anthony V AV Heidenreich Olaf O Vormoor Josef J
Cell reports. Medicine 20220801 8
Leukemia cells re-program their microenvironment to augment blast proliferation and enhance treatment resistance. Means of clinically targeting such niche-driven treatment resistance remain ambiguous. We develop human induced pluripotent stem cell (hiPSC)-engineered niches to reveal druggable cancer-niche dependencies. We reveal that mesenchymal (iMSC) and vascular niche-like (iANG) hiPSC-derived cells support ex vivo proliferation of patient-derived leukemia cells, affect dormancy, and mediate ...[more]