Ontology highlight
ABSTRACT:
SUBMITTER: Hsu CG
PROVIDER: S-EPMC9433404 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Hsu Chia George CG Chávez Camila Lage CL Zhang Chongyang C Sowden Mark M Yan Chen C Berk Bradford C BC
Cell death and differentiation 20220309 9
Pyroptosis is a form of cell death triggered by the innate immune system that has been implicated in the pathogenesis of sepsis and acute lung injury. At the cellular level, pyroptosis is characterized by cell swelling, membrane rupture, and release of inflammatory cytokines, such as IL-1β. However, the role of endogenous lipids in pyroptosis remains underappreciated. We discovered that 4-hydroxynonenal (HNE), a major endogenous product of lipid peroxidation, inhibited pyroptosis and inflammasom ...[more]