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Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis.


ABSTRACT: Temperament involves stable behavioral and emotional tendencies that differ between individuals, which can be first observed in infancy or early childhood and relate to behavior in many contexts and over many years.1 One of the most rigorously characterized temperament classifications relates to the tendency of individuals to avoid the unfamiliar and to withdraw from unfamiliar people, objects, and unexpected events. This temperament is referred to as behavioral inhibition or inhibited temperament (IT).2 IT is a moderately heritable trait1 that can be measured in multiple species.3 In humans, levels of IT can be quantified from the first year of life through direct behavioral observations or reports by caregivers or teachers. Similar approaches as well as self-report questionnaires on current and/or retrospective levels of IT1 can be used later in life.

SUBMITTER: Bas-Hoogendam JM 

PROVIDER: S-EPMC9434711 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis.

Bas-Hoogendam Janna Marie JM   Bernstein Rachel R   Benson Brenda E BE   Buss Kristin A KA   Gunther Kelley E KE   Pérez-Edgar Koraly K   Salum Giovanni A GA   Jackowski Andrea P AP   Bressan Rodrigo A RA   Zugman André A   Degnan Kathryn A KA   Filippi Courtney A CA   Fox Nathan A NA   Henderson Heather A HA   Tang Alva A   Zeytinoglu Selin S   Harrewijn Anita A   Hillegers Manon H J MHJ   White Tonya T   van IJzendoorn Marinus H MH   Schwartz Carl E CE   Felicione Julia M JM   DeYoung Kathryn A KA   Shackman Alexander J AJ   Smith Jason F JF   Tillman Rachael M RM   van den Berg Yvonne H M YHM   Cillessen Antonius H N AHN   Roelofs Karin K   Tyborowska Anna A   Hill Shirley Y SY   Battaglia Marco M   Tettamanti Marco M   Dougherty Lea R LR   Jin Jingwen J   Klein Daniel N DN   Leung Hoi-Chung HC   Avery Suzanne N SN   Blackford Jennifer Urbano JU   Clauss Jacqueline A JA   Hayden Elizabeth P EP   Liu Pan P   Vandermeer Matthew R J MRJ   Goldsmith H Hill HH   Planalp Elizabeth M EM   Nichols Thomas E TE   Thompson Paul M PM   Westenberg P Michiel PM   van der Wee Nic J A NJA   Groenewold Nynke A NA   Stein Dan J DJ   Winkler Anderson M AM   Pine Daniel S DS  

Journal of the American Academy of Child and Adolescent Psychiatry 20220613 9


Temperament involves stable behavioral and emotional tendencies that differ between individuals, which can be first observed in infancy or early childhood and relate to behavior in many contexts and over many years.<sup>1</sup> One of the most rigorously characterized temperament classifications relates to the tendency of individuals to avoid the unfamiliar and to withdraw from unfamiliar people, objects, and unexpected events. This temperament is referred to as behavioral inhibition or inhibite  ...[more]

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