Dataset Information

InPhocus: Current State and Challenges of Phage Research in Singapore.

ABSTRACT: Bacteriophages and phage-derived proteins are a promising class of antibacterial agents that experience a growing worldwide interest. To map ongoing phage research in Singapore and neighboring countries, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore (NTU) and Yong Loo Lin School of Medicine, National University of Singapore (NUS) recently co-organized a virtual symposium on Bacteriophage and Bacteriophage-Derived Technologies, which was attended by more than 80 participants. Topics were discussed relating to phage life cycles, diversity, the roles of phages in biofilms and the human gut microbiome, engineered phage lysins to combat polymicrobial infections in wounds, and the challenges and prospects of clinical phage therapy. This perspective summarizes major points discussed during the symposium and new perceptions that emerged after the panel discussion.

SUBMITTER: Verma NK

PROVIDER: S-EPMC9436264 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Publications

inPhocus: Current State and Challenges of Phage Research in Singapore.

Verma Navin Kumar NK Tan Si Jia SJ Chen John J Chen Hanrong H Ismail Muhammad Hafiz MH Rice Scott A SA Bifani Pablo P Hariharan Sukumar S Paul Vivek Daniel VD Sriram Bharathi B Dam Linh Chi LC Chan Chia Ching CC Ho Peiying P Goh Boon Chong BC Chung Shimin Jasmine SJ Goh Kenneth Choon Meng KCM Thong Shu Hua SH Kwa Andrea Lay-Hoon AL Ostrowski Adam A Aung Thet Tun TT Razali Halimah H Low Shermaine W Y SWY Bhattacharyya Mani Shankar MS Gautam Hemant K HK Lakshminarayanan Rajamani R Sicheritz-Pontén Thomas T Clokie Martha R J MRJ Moreira Wilfried W van Steensel Maurice Adrianus Monique MAM

PHAGE (New Rochelle, N.Y.) 20220318 1

Bacteriophages and phage-derived proteins are a promising class of antibacterial agents that experience a growing worldwide interest. To map ongoing phage research in Singapore and neighboring countries, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore (NTU) and Yong Loo Lin School of Medicine, National University of Singapore (NUS) recently co-organized a virtual symposium on Bacteriophage and Bacteriophage-Derived Technologies, which was attended by more than 80 pa ...[more]

PMID: 36161195

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Project description:BackgroundBlockchain offers a promising new distributed technology to address the challenges of data standardization, system interoperability, security, privacy, and accessibility of medical records.ObjectiveThe purpose of this review is to assess the research on the use of blockchain technology for patient care and the associated challenges and to provide a research agenda for future research.MethodsThis review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. We queried the Cumulative Index of Nursing and Allied Health Literature (CINAHL), PubMed, Excerpta Medica dataBASE (EMBASE), and Web of Science databases for peer-reviewed research articles published up to December 2019 that examined the implementation of blockchain technology in health care settings. We identified 800 articles from which we selected 70 empirical research articles for a detailed review.ResultsBlockchain-based patient care applications include medical information systems, personal health records, mobile health and telemedicine, data preservation systems and social networks, health information exchanges and remote monitoring systems, and medical research systems. These blockchain-based health care applications may improve patient engagement and empowerment, improve health care provider access to information, and enhance the use of health care information for medical research.ConclusionsBlockchain health information technology (HIT) provides benefits such as ensuring data privacy and security of health data, facilitating interoperability of heterogeneous HIT systems, and improving the quality of health care outcomes. However, barriers to using blockchain technology to build HIT include security and privacy vulnerabilities, user resistance, high computing power requirements and implementation costs, inefficient consensus algorithms, and challenges of integrating blockchain with existing HIT. With 51% of the research focused on medical information systems such as electronic health record and electronic medical record, and 53% of the research focused on data security and privacy issues, this review shows that HIT research is primarily focused on the use of blockchain technologies to address the current challenges HIT faces. Although Blockchain presents significant potential for disrupting health care, most ideas are in their infancy.

Dataset Information

InPhocus: Current State and Challenges of Phage Research in Singapore.

Publications

inPhocus: Current State and Challenges of Phage Research in Singapore.

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