Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress.
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ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC9436817 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Publications
Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress.
Chen Yihong Y Shen Junyan J Nilsson Anna Hultgårdh AH Goncalves Isabel I Edsfeldt Andreas A Engström Gunnar G Zaigham Suneela S Melander Olle O Orho-Melander Marju M Rauch Uwe U Venuraju Shreenidhi M SM Lahiri Avijit A Liang Chun C Nilsson Jan J
JACC. Basic to translational science 20220720 8
Hepatocyte growth factor (HGF) is released by stressed human vascular cells and promotes vascular cell repair responses in both autocrine and paracrine ways. Subjects with a low capacity to express HGF in response to systemic stress have an increased cardiovascular risk. Human atherosclerotic plaques with a low content of HGF have a more unstable phenotype. The present study shows that subjects with a low ability to express HGF in response to metabolic stress have an increased risk to suffer myo ...[more]
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