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SARS-CoV-2 mRNA-vaccine candidate; COReNAPCIN®, induces robust humoral and cellular immunity in mice and non-human primates.


ABSTRACT: At the forefront of biopharmaceutical industry, the messenger RNA (mRNA) technology offers a flexible and scalable platform to address the urgent need for world-wide immunization in pandemic situations. This strategic powerful platform has recently been used to immunize millions of people proving both of safety and highest level of clinical efficacy against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we provide preclinical report of COReNAPCIN®; a vaccine candidate against SARS-CoV-2 infection. COReNAPCIN® is a nucleoside modified mRNA-based vaccine formulated in lipid nanoparticles (LNPs) for encoding the full-length prefusion stabilized SARS-CoV-2 spike glycoprotein on the cell surface. Vaccination of C57BL/6 and BALB/c mice and rhesus macaque with COReNAPCIN® induced strong humoral responses with high titers of virus-binding and neutralizing antibodies. Upon vaccination, a robust SARS-CoV-2 specific cellular immunity was also observed in both mice and non-human primate models. Additionally, vaccination protected rhesus macaques from symptomatic SARS-CoV-2 infection and pathological damage to the lung upon challenging the animals with high viral loads of up to 2 × 108 live viral particles. Overall, our data provide supporting evidence for COReNAPCIN® as a potent vaccine candidate against SARS-CoV-2 infection for clinical studies.

SUBMITTER: Alimohammadi R 

PROVIDER: S-EPMC9438359 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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SARS-CoV-2 mRNA-vaccine candidate; COReNAPCIN<sup>®</sup>, induces robust humoral and cellular immunity in mice and non-human primates.

Alimohammadi Reza R   Porgoo Meysam M   Eftekhary Mohamad M   Kiaie Seyed Hossein SH   Ansari Dezfouli Ehsan E   Dehghani Maryam M   Nasrollahi Kaveh K   Malekshahabi Talieh T   Heidari Maryam M   Pouya Sedigheh S   Alimohammadi Masoumeh M   Sattari Khavas Dorsa D   Modaresi Mohammad Sadra MS   Ghasemi Mohammad Hossein MH   Ramyar Hamed H   Mohammadipour Fatemeh F   Hamzelouei Fateme F   Mofayezi Ahmadreza A   Mottaghi Seyed Saeed SS   Rahmati Amirhosein A   Razzaznian Mohsen M   Tirandazi Vista V   Tat Mahdi M   Borzouee Fatemeh F   Sadeghi Hossein H   Haji Mohammadi Melika M   Rastegar Leila L   Safar Sajadi Seyed Milad SM   Ehsanbakhsh Hossein H   Bazmbar Hamed H   Baghernejadan Zeinab Z   Shams Nouraei Maedeh M   Pazooki Pouya P   Pahlavanneshan Mina M   Alishah Khadijeh K   Nasiri Fateme F   Mokhberian Neda N   Mohammadi Seyedeh Shima SS   Akar Shima S   Niknam Hamidreza H   Azizi Marzieh M   Ajoudanian Mohammad M   Moteallehi-Ardakani Mohammad Hossein MH   Mousavi Shaegh Seyed Ali SA   Ramezani Reihaneh R   Salimi Vahid V   Moazzami Reza R   Hashemi Seyed Mahmoud SM   Dehghanizadeh Somaye S   Khoddami Vahid V  

NPJ vaccines 20220902 1


At the forefront of biopharmaceutical industry, the messenger RNA (mRNA) technology offers a flexible and scalable platform to address the urgent need for world-wide immunization in pandemic situations. This strategic powerful platform has recently been used to immunize millions of people proving both of safety and highest level of clinical efficacy against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we provide preclinical report of COReNAPCIN<sup>®</sup>; a  ...[more]

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