Ontology highlight
ABSTRACT:
SUBMITTER: Cleary JM
PROVIDER: S-EPMC9440204 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Cleary James M JM Rouaisnel Betty B Daina Antoine A Raghavan Srivatsan S Roller Lauren A LA Huffman Brandon M BM Singh Harshabad H Wen Patrick Y PY Bardeesy Nabeel N Zoete Vincent V Wolpin Brian M BM Losman Julie-Aurore JA
NPJ precision oncology 20220902 1
The mutant IDH1 inhibitor ivosidenib improves outcomes for patients with IDH1-mutated cholangiocarcinoma, but resistance inevitably develops. Mechanisms of resistance and strategies to overcome resistance are poorly understood. Here we describe two patients with IDH1 R132C-mutated metastatic cholangiocarcinoma who developed acquired resistance to ivosidenib. After disease progression, one patient developed an oncogenic IDH2 mutation, and the second patient acquired a secondary IDH1 D279N mutatio ...[more]