Ontology highlight
ABSTRACT:
SUBMITTER: Feng Q
PROVIDER: S-EPMC9448806 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Feng Qiang Q Liu Zhida Z Yu Xuexin X Huang Tongyi T Chen Jiahui J Wang Jian J Wilhelm Jonathan J Li Suxin S Song Jiwon J Li Wei W Sun Zhichen Z Sumer Baran D BD Li Bo B Fu Yang-Xin YX Gao Jinming J
Nature communications 20220906 1
Lactate is a key metabolite produced from glycolytic metabolism of glucose molecules, yet it also serves as a primary carbon fuel source for many cell types. In the tumor-immune microenvironment, effect of lactate on cancer and immune cells can be highly complex and hard to decipher, which is further confounded by acidic protons, a co-product of glycolysis. Here we show that lactate is able to increase stemness of CD8<sup>+</sup> T cells and augments anti-tumor immunity. Subcutaneous administrat ...[more]